Duplex Healing of Selectively Thiolated Guanosine Mismatches through a Cd2+ Chemical Stimulus
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چکیده
منابع مشابه
The structure of guanosine-thymidine mismatches in B-DNA at 2.5-A resolution.
The structure of the deoxyoligomer d(C-G-C-G-A-A-T-T-T-G-C-G) was determined at 2.5-A resolution by single crystal x-ray diffraction techniques. The final R factor is 18% with the location of 71 water molecules. The oligomer crystallizes in a B-DNA-type conformation, with two strands interacting to form a dodecamer duplex. The double helix consists of four A X T and six G X C Watson-Crick base ...
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15 صفحه اولStructure-function relationships of phenoxazine nucleosides for identification of mismatches in duplex DNA by fluorescence spectroscopy.
The effects of the flanking sequence on the mismatch-detection capabilities of the fluorescent nucleoside phenoxazine (tC(O)) were examined in a systematic fashion, and compared to the previously reported fluorescent, phenoxazine-based nucleoside Ç(f) . We see some similarities for the two fluorescent nucleosides, for example, the emission intensity of the C-mismatched duplex is always the high...
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The spin-labeled nucleoside (T)C, containing 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) conjugated to the exocyclic amino group of C, was used to detect single-base mismatches in duplex DNA for the first time by electron paramagnetic resonance (EPR) spectroscopy. Furthermore, the EPR spectra of the fully base-paired duplex ((T)C.G) and the mismatches ((T)C.A, (T)C.C, and (T)C.T) were signific...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2018
ISSN: 1439-4227
DOI: 10.1002/cbic.201800100